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Kappa/Lambda Ratio

The kappa/lambda ratio is a crucial diagnostic marker in multiple myeloma and other plasma cell disorders. It measures the ratio of two types of free light chains, kappa and lambda, in the blood. In healthy individuals, plasma cells produce a balanced amount of kappa and lambda light chains, maintaining a normal ratio (typically between 0.26 and 1.65).

An abnormal kappa/lambda ratio can indicate the overproduction of one type of light chain, which is often associated with multiple myeloma or related conditions. A high ratio suggests excess kappa chains, while a low ratio indicates excess lambda chains. This imbalance helps doctors diagnose the specific type of multiple myeloma and monitor disease activity and treatment effectiveness.

 

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