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Armpit Rash with Multiple Myeloma: What You Need to Know

Writer's picture: Polygon Health TeamPolygon Health Team

Updated: Oct 31, 2024


For people living with multiple myeloma, monitoring your health changes and symptoms is important to maintain a healthy lifestyle. Some MM symptoms can indicate bigger underlying issues or potential complications. An armpit rash, while often harmless, can raise concerns for multiple myeloma patients, especially if it comes with other symptoms. Here’s what multiple myeloma patients should know about armpit rashes, potential links to their condition, and when to consult their healthcare team.


Understanding Armpit Rash in Multiple Myeloma Patients


Armpit Rash with Multiple Myeloma: What You Need to Know

An armpit rash can have many benign causes, such as allergic reactions, skin irritation, or infections, but multiple myeloma patients should be mindful of the specific risks associated with their condition. The immune system in multiple myeloma patients can be weakened due to both the disease and treatments like chemotherapy, which increases vulnerability to infections and other skin issues. Here are some common causes of armpit rash for multiple myeloma patients:


  1. Allergic Reactions: Sensitivity to skincare products, soaps, or laundry detergents can irritate sensitive skin, causing redness, itching, and a rash.


  2. Infections: Fungal or bacterial infections are more common in those with weakened immune systems. The warm environment in the armpits can easily foster these infections, leading to red, itchy patches that may require antifungal or antibiotic treatments.


  3. Heat Rash: In warmer climates or after exertion, excessive sweating can clog sweat ducts, causing a red, bumpy rash


  4. Reactions to Medications: Multiple myeloma treatments, including chemotherapy and immunotherapy, may cause skin side effects. Some patients experience rashes as a reaction to their medications, which may appear in sensitive areas like the armpits.


Can an Armpit Rash Be a Sign of Complications in Multiple Myeloma?


While armpit rashes are rarely a direct sign of cancer, multiple myeloma can sometimes lead to symptoms that overlap with armpit rash, particularly in cases of infections or enlarged lymph nodes. Here are a few potential scenarios to be aware of:


1. Weakened Immune System and Infections


Multiple myeloma and its treatments often weaken the immune system, increasing susceptibility to infections. An armpit rash could be a localized bacterial or fungal infection, which requires prompt treatment to avoid spreading or worsening. These infections may start as red or itchy patches and can spread or become painful if untreated. Signs of infection that require immediate attention include:


  • Redness that spreads beyond the armpit area

  • Increased warmth or tenderness in the affected area

  • Fever or chills

  • Swollen lymph nodes


For multiple myeloma patients, even a minor infection should be taken seriously and managed promptly.


2. Lymphadenopathy (Swollen Lymph Nodes)


Swollen lymph nodes in the armpits could signal that the body is fighting an infection, but in some cases, swollen nodes may relate to blood cancer complications. For multiple myeloma patients, swollen armpit lymph nodes might indicate an immune response or a more complex health concern. Accompanying symptoms to watch for include:


  • Persistent lumps or hard masses in the armpit

  • Fatigue and general discomfort

  • Fever or night sweats


Multiple myeloma patients experiencing these symptoms should consult their healthcare provider, who may conduct imaging tests or bloodwork to investigate further.


3. Treatment-Related Skin Reactions


Some multiple myeloma treatments can cause rashes or skin irritation, especially on sensitive skin areas like the armpits. These rashes may appear red, itchy, and patchy and can sometimes be mistaken for an infection or allergic reaction. It’s helpful to track any changes and report them to your care team, as they may adjust medication or suggest treatments to reduce irritation.


When Should Multiple Myeloma Patients Be Concerned About an Armpit Rash?


While most armpit rashes are benign, it’s crucial for multiple myeloma patients to be vigilant, especially if the rash doesn’t respond to standard treatments or worsens over time. Consider reaching out to your healthcare team if you experience:


  • Persistent or Worsening Rash: If a rash doesn’t improve after a week or with basic treatments, it’s worth discussing with your doctor.

  • Swelling or Hard Lumps: Any new or persistent lumps should be evaluated, as they could indicate swollen lymph nodes or another immune response.

  • Additional Symptoms: Rashes accompanied by fever, night sweats, or weight loss may suggest an underlying issue that requires medical attention.

  • Painful or Spreading Rash: If the rash becomes increasingly painful, warm, or spreads, it may be a sign of infection that needs prompt treatment.


A general rule is to contact your healthcare provider if any new symptom, including a rash, doesn’t resolve with standard care or seems to be related to your multiple myeloma or its treatments.


What to Expect When Visiting Your Doctor for an Armpit Rash


If you decide to consult your healthcare team about an armpit rash, they will likely perform a physical exam, ask about recent treatments, and review your medical history to understand possible causes. Here’s what might be involved:


  1. Physical Examination: Your doctor will examine the rash, noting its appearance, location, and any surrounding lumps.


  2. Blood Tests: Bloodwork can help identify infections or other immune-related issues, especially if multiple myeloma or its treatments have compromised your immune system.


  3. Imaging Tests: If there’s swelling or a lump in the armpit, imaging (like an ultrasound) may be used to get a closer look and rule out more severe concerns


  4. Medication Adjustments: If the rash is a reaction to treatment, your doctor may recommend alternative medications or suggest ways to manage the skin irritation.


Managing Armpit Rashes in Multiple Myeloma Patients


Most armpit rashes can be managed at home with simple remedies, but multiple myeloma patients should approach these treatments with added caution due to their unique health needs:


  • Antifungal or Antibiotic Creams: If the rash is caused by a fungal or bacterial infection, your doctor may prescribe medicated creams.

  • Moisturizers and Sensitive-Skin Products: Use gentle, fragrance-free lotions and soaps to avoid further irritation.

  • Avoid Scratching: As tempting as it might be, scratching can lead to further irritation or infection, especially if your immune system is compromised.

  • Consult with Your Doctor Before Using Over-the-Counter Treatments: Given the immune considerations in multiple myeloma, ask your healthcare provider before trying new treatments, even for minor skin irritations.


Key Takeaways for Multiple Myeloma Patients


An armpit rash is rarely a cause for serious concern, but it’s always wise to monitor any new or persistent symptoms, especially for multiple myeloma patients. Living with a weakened immune system makes you more susceptible to infections, so prompt attention to new symptoms can prevent minor issues from becoming bigger problems.


If you want to discuss more, comment below or go to Patient Connect and share your story. If you or a loved one are concerned about multiple myeloma, consult with a healthcare professional to discuss risk factors, screening options, and next steps.

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